Hyperekplexia: a surprise diagnosis

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Neonatal Hyperekplexia: A Case Report

Hyperekplexia is a rare non-epileptic disorder characterized by an exaggerated and persistent startle reaction to the unexpected tactile and acoustic stimuli. The disorder is occasionally associated with generalized muscular rigidity and has the clinical hallmark of positive nose tapping test.The disease is inherited in an autosomal dominant fashion.  Recessively inherited and sporadic forms of...

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Sporadic Hyperekplexia Plus Syndrome

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Late onset hyperekplexia.

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Hyperekplexia in neonates.

Hyperekplexia (startle disease) is a rare non-epileptic disorder characterised by an exaggerated persistent startle reaction to unexpected auditory, somatosensory and visual stimuli, generalised muscular rigidity, and nocturnal myoclonus. The genetic basis is a mutation usually of the arginine residue 271 leading to neuronal hyperexcitability by impairing glycinergic inhibition. Hyperekplexia i...

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ژورنال

عنوان ژورنال: Neurologia i Neurochirurgia Polska

سال: 2020

ISSN: 1897-4260,0028-3843

DOI: 10.5603/pjnns.a2020.0057